ChREBP is basically gene expression induced by carbohydrate consumption, Lucas Tufar has blogged about it here, I say destiny in the title because nuclear receptor binding is inevitable. ( aslong as your not some kind of freakish mutant ) Nuclear receptor binding is the definition of gene expression, and ChREBP is involved right at the nuclear level, right next to your DNA.
- ChREBP activates downstream target genes, including fatty acid synthase
- leading to lipid accumulation, increased oxidative stress, reduced insulin gene transcription/secretion
- and enhanced apoptosis ( wweeeeeeee, self-destructing beta cells is good for your health )
- beta cell-specific Chrebp overexpression is sufficient to phenocopy glucotoxicity
All of this is irrelevant ofcourse because we all know the problem is too much dietary fat.