Sunday, 3 March 2013

Duodenal bypass resolves Type 2 Diabetes without weight loss

This is an interesting case report ( N=1 ) of a 52yr old female that had her severe Type 2 diabetes resolve after a surgical reconstruction of the gut that involves bypass of the duodenum.


Roux-en-Y gastric bypass (RYGB) results in complete remission of type 2 diabetes mellitus (T2DM) in 80–85% of cases, often before substantial weight loss has occurred [1]. Mounting evidence indicates that this remarkable effect results from mechanisms other than just reductions in food intake and body weight. Among the implicated weightindependent antidiabetes mechanisms, a role has been hypothesized for physiologic changes caused by excluding the proximal intestine from contact with the ingested nutrients [2]. We provide evidence supporting that assertion in the present case report.

To put this into perspective, this woman's BMI was 31.1, so clearly not massively fat, again throwing a wrench into the idea that "fatnass" causes insulin resistance causes diabetes. She was on 2g metformin + 2g glimepiride per day but still had a HbA1c of 7.5% and a fasting glucose of 154. So clearly, despite a BMI that just passes the "obesity" threshold, she is massively insulin resistant.

Initially she undergoes a Billroth I intestinal reconstruction to treat her refractory peptic ulcer disease, but then 10 years later ( during which time her T2DM has gotten even worse and she is now also on maximum dose pioglitazone, with fasting glucose 165 )  she presents with refractory alkaline reflux gastritis which is a known complication of the Billroth I gastric reconstruction. Oh, and her BMI has since dropped to 30.1, so although she has lost weight, she has since become even more insulin resistant.

Confused yet?

Anyway, she now has her Billroth I changed into a Roux-en-Y gastric reconstruction to cure the alkaline reflux, but unlike severely obese patients undergoing Roux-en-Y,  this ladies stomach is not reduced in size so that she can still eat normal amounts of food. Here's a picture from the .pdf showing diagrams of the different surgeries.




After the Roux-en-Y surgery, she experiences further weight loss of ~1kg over 6 months, but surprisingly, her T2DM quickly resolves. The lady also reports no significant changes in diet or food intake! 3 days after surgery, her fasting glucose dropped to ~98. So basically, simply bypassing the duodenum and stopping it from interacting with food *cured* her massive insulin resistance. The lady stopped all diabetic medication 3months after surgery and 2 years later her diabetes was still resolved.

The only caveat mentioned by the authors of the Case Report is that, in patients undergoing duodenal bypass WITHOUT diabetes they experience a slight worsening of glucose tolerance.

OK anyway, whats going on here? Her fasting insulin is never mentioned in the report, so I can only speculate, but I think this is what changed and is what allowed her resolve her T2DM. As described in this post,  Pories et al says that foregut bypass usually lowers fasting hyperinsulinemia, which in turn, corrects insulin resistance.

Cases like this not only blow a hole in the idea that fatness causes insulin resistance, but also make me doubt the mitochondrial disease theory of obesity/T2DM, I mean, how would you explain that simply byspassing the foregut *cures* your sick diseased mitochondria?

Also, one possible explanation for why people can become T2DM at lower BMI's might be explained by the speed at which your fasting hyperinsulinemia develops. If the increase in fasting hyperinsulinemia develops very quickly, you may end up becoming very quickly severely IR in adipose tissue, which would curb weight gain.

Pories et al had some interesting quotes at the end of their paper.....

We do not treat hyperthyroidism with thyroxine, or Cushing Syndrome with cortisone, should we be treating T2DM, a disease characterized by hyperinsulinemia, with insulin?

Lowering insulin can make you more insulin sensitive, and if your more insulin sensitive then you need less insulin to actually achieve what it is your trying to do. For example, if serum FFA is too high because FFA leak from adipocytes is high, you might immediately think thats because insulin resistance in adipocytes is too high or that the pancreas isnt producing enough insulin to "overcome" the insulin resistance.

Counter-intuitively, it could be argued that insulin is chronically too high, making adipocytes severely insulin resistant and causing them to leak FFA. Lowering insulin would in turn make the adipocytes more insulin sensitive, and then, youd actually need less insulin to control the FFA leak.

Pories et al also had this to say......

it seems reasonable to propose that a diabetogenic signal from the gut is the cause of hyperinsulinemia. 

Although im sure Pories et al had considered this, the thing that comes to *my* mind here is GIP,  Glucose-Dependent Insulinotropic Polypeptide, which is secreted from the K-cells which mostly inhabit the duodenum. As its name suggests, the main job of this hormone is to increase insulin secretion induced by intestinally absorbed nutrients, but it also stimulates fat uptake by adipocytes by stimulating LPL ( link ).

Both fats and carbohydrates are very strong stimulants for GIP secretion, whereas protein is only a weak stimulus for secretion.

Data have shown that obese and type 2 diabetic subjects have an increased response to GIP secretion after the ingestion of a meal (10, 77). In fact, GIP has been established as a possible link between overnutrition and obesity.
High-fat diets increase GIP secretion in part via increased K cell transcription and proliferation and might represent the stimulus for insulin hypersecretion and insulin resistance (32). In human obesity, elevated basal and nutrient-stimulated GIP are associated with glucose intolerance and hyperinsulinemia ( link )

Ignoring the high-fat diet part, I think this is a good explanation for why rodents can become hyperinsulinemic on high-fat diets, proliferation of K-cells in the gut would increase the secretion of GIP in response to fats and thus start an insulin secretion snowball. As im aware, humans do not become hyperinsulinemic on ketogenic diets, so im not sure if this finding translates to humans so easily, but remember that GIP only causes insulin secretion in the presence of glucose, this is why eating fat alone, although it stimulates a GIP response, produces only a tiny insulin response.

HOWEVER,  the idea that k-cell proliferation causes GIP hypersecretion causes insulin hypersecretion was the theory I was considering. But that simply other things other than fats might be causing the K-cell proliferation, for example dense sources of acellular carbohydrates.

With the limitation that we could not establish a causal relationship between events, our study shows that HFD stimulates duodenal proliferation of endocrine cells differentiating towards K cells and oversecreting GIP. The progressive increment of GIP levels might represent the stimulus for insulin hypersecretion and insulin resistance. ( link )

So, nothing is set in stone yet, If we look at the diagram below we can see "why" K-cell proliferation would cause hypersecretion of GIP.....




If you look at the red circle, you can see that there are distinct cells that secrete hormones, and that they are different to the cells that absorb food in the GI tract. So, the more of those green hormone secreting cells you have, the more hormone your going to secrete in response to the same food amount.

OK, to sum up, what I was getting at here is that *possibly*, duodenal bypass cured T2DM by curing fasting hyperinsulinemia, which in turn was cured by bypassing the duodenum where most of the K-cells are situated, which secrete GIP. And also that possibly, K-cell proliferation results in GIP hypersecretion which in turn results in fasting hyperinsulinemia.









8 comments:

  1. I feel this is a stupid question but...
    Is it possible that her surgery made her unable to absorb glucose (but not protein and fat)? If she used to eat a lot of glucose, her appetite might have increased a bit so that she ate more of everything and her weight barely moved, but her glycemia decreased greatly. No?

    ReplyDelete
    Replies
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  2. This type of surgery probably reduces absorption of *some* food, but I dont think there would be any differences between protein or carb, Fat might get absorbed less because it needs the bile to be properly digested. Im not sure overall because I havent done the research into food absorption in Roux-enY surgery.

    BUT, the point is this ladies fasting glucose corrected at only 3 days after surgery, which if nothing is indicative of a massive drop in insulin resistance.

    ReplyDelete
  3. http://www.news-medical.net/news/2005/10/12/13727.aspx

    --------------------------------------------------------------
    The study details the history of three patients, who did not have diabetes, who suffered such severe hypoglycemia following meals that they became confused and sometimes blacked out, in two cases causing automobile collisions. The immediate cause of hypoglycemia was exceptionally high levels of insulin following meals. All three patients in the collaborative study failed to respond to medication, and ultimately required partial or complete removal of the pancreas, the major source of insulin, to prevent dangerous declines in blood glucose.

    "Severe hypoglycemia is a complication of gastric bypass surgery, and should be considered if the patient has symptoms such as confusion, lightheadedness, rapid heart rate, shaking, sweating, excessive hunger, bad headaches in the morning or bad nightmares," says Mary-Elizabeth Patti, M.D., Investigator in Joslin's Research Section on Cellular and Molecular Physiology and Assistant Professor of Medicine at Harvard Medical School. "If these symptoms don't respond to simple changes in diet, such as restricting intake of simple carbohydrates, patients should be evaluated hormonally, quickly," she adds. Dr. Patti and Allison B. Goldfine, M.D., also an Investigator at Joslin and Assistant Professor of Medicine at Harvard Medical School, were co-investigators of the study.
    ---------------------------------------------------------------------------

    Sort of a different outcome here, in non-diabetics. In these cases, maybe it wasn't the hyperinsulinism causing hypoglycemia, so much as the inability of the body to protect itself against hypoglycemia from hyperinsulin (and if obesity sometimes protects from an extreme hypoglycemia--if this was the body's other option, you could see how obesity could be a reasonable adaptation. Obesity kills slow, hypoglycemia can kill fast).

    These poor people and their pancreases are maybe examples of what can happen if hyperinsulinism is ignored as a possible cause of obesity. Guyunet makes the argument that hypoglycemia is only mild when they test it in most people with hypoglycemic symptoms. But, have they been forced to eat in a manner that minimizes hypoglycemic responses on their habitual diet? On the SAD, one protective option might be getting fat.

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    Replies
    1. Ineresting indeed, I wonder if the postprandial insulin hypersecretions were present before the surgery but was compensated for by their insulin resistance, and so no symptoms were apparent. Perhaps the surgery corrected their fasting hyperinsulinemia and insulin resistance but the pancreas remained a hyper-secreter but since theyre now insulin sensitive, the insulin surges is causing hypoglycemia.

      Another possibility is the exaggerated glp-1 secretions common with gastric bypass , causing beta cell growth and thus explains the eventual insulin-hypersecretions.

      I need to remind myself that although surgery can offer interesting insights into physiology I should remember that these GI tract reconstructions are completely unnatural and not found normally in nature, and so conclusions drawn from GI tract reconstructions must be considered with caution.

      Delete
    2. I think that explanation is starting to become "accepted" as a cause of post-GB hypoglycemia. aka "Nesidioblastosis"

      Delete
  4. Hi Kindke,
    Nice post -
    "how would you explain that simply byspassing the foregut *cures* your sick diseased mitochondria"
    very interesting observation +1.

    Alternatively, maybe the mitochondria are still sick & diseased but the surgery enhanced an unrelated factor that overcompensated, resulting in net improvement?

    ReplyDelete
  5. Each year, 11,000 People Saw Their Type 2 Diabetes Mysteriously REVERSED, But Even Their Doctors Couldn’t Say Why

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    ReplyDelete